Skip to Main Content (Press Enter)
×
Home
Persone
Pubblicazioni
Strutture
Competenze
IT
EN
☰
UNI-FIND
|
UNI-FIND
cnr.it
IT
EN
×
Home
Persone
Pubblicazioni
Strutture
Competenze
☰
Pubblicazioni
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Rivista
Codice:
E060692
ISSN:
0223-5234
Dati Generali
Dati Generali
Pubblicazioni (123)
Pulisci
Ordina Pubblicazioni:
ascendente
decrescente
(2
S
)-
N
-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2
S
-LP2): Discovery of a biased mu/delta opioid receptor agonist
Articolo
1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB(1) or CB(2) receptor ligands.
Articolo
1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands.
Articolo
2/4-Substituted-9-fluorenones and their O-glucosides as potential immunomodulators and anti-herpes simplex virus-2 agents. Part 5
Articolo
A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-Tetrahydrobenzo[6,7]cyclohepta[1,2-c ]pyrazole-3-carboxamide and analogue derivatives
Articolo
A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(20,40-dichlorophenyl)-N-piperidin-1-yl- 1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives
Articolo
A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAFV600E in cancer cells
Articolo
A novel 2,3-diphenyl-4H-pyrido[1,2-a]pyrimidin-4-one derivative inhibits endothelial cell dysfunction and smooth muscle cell proliferation/activation
Articolo
An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors
Articolo
Anti-inflammatory effects of flavonoids in neurodegenerative disorders
Articolo
Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease
Articolo
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability
Articolo
Benzothienoquinazolinones as new multi-target scaffolds: Dual inhibition of human Topoisomerase I and tubulin polymerization
Articolo
Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: Modulation at the N-portion and distal phenyl ring
Articolo
Bifunctional compounds targeting both D-2 and non-alpha 7 nACh receptors: Design, synthesis and pharmacological characterization
Articolo
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors
Articolo
Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation
Articolo
Chemical modifications in the seed region of miRNAs 221/222 increase the silencing performances in gastrointestinal stromal tumor cells.
Articolo
Computational analysis of ligand recognition sites of homo- and heteropentameric 5-HT3 receptors
Articolo
Conformational studies of chiral d-Lys-PNA and achiral PNA system in binding with DNA or RNA through a molecular dynamics approach
Articolo
Conformationally constrained analogues of endogenous tripeptide inhibitors of zinc metalloproteinases.
Articolo
DDX3X Inhibitors, an Effective Way to Overcome HIV-1 Resistance Targeting Host Proteins
Articolo
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R)
Articolo
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy
Articolo
Design and synthesis of novel 3,4-disubstituted pyrazoles for nanomedicine applications against malignant gliomas
Articolo
Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities for alpha(4)beta(2) neuronal nicotinic acetylcholine receptors
Articolo
Design, structural and biological characterization of a VEGF inhibitor beta-hairpin-constrained peptide
Articolo
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-JK]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase
Articolo
Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as a b-amyloid aggregation inhibitors.
Articolo
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
Articolo
Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors
Articolo
Differential scanning calorimetry approach to investigate the transfer of the multitarget opioid analgesic LP1 to biomembrane model
Articolo
Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for ? Opioid receptor for Safer and long-lasting analgesia
Articolo
Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality
Articolo
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment
Articolo
Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal
Articolo
Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3
Articolo
Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies
Articolo
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl) benzenesulfonamide moiety
Articolo
Exploring the anticancer potential of pyrazolo[1,2-a]benzo[1,2,3,4] tetrazin-3-one derivatives: The effect on apoptosis induction, cell cycle and proliferation
Articolo
First dual AK/GSK-3beta inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents
Articolo
Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach
Articolo
From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at ?4?2 nicotinic acetylcholine receptor
Articolo
Homology modeling in tandem with 3D-QSAR analyses: a computational approach to depict the agonist binding site of the human CB2 receptor
Articolo
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus
Articolo
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease
Articolo
Hydroxylated biphenyls as tyrosinase inhibitor: A spectrophotometric and electrochemical study
Articolo
Identification of 2,4,5-trisubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one-based small molecules as selective BRD9 binders
Articolo
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase
Articolo
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma
Articolo
In silico drug repositioning on F508del-CFTR: A proof-of-concept study on the AIFA library
Articolo
Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases
Articolo
Iodo and diiodotyrosine epoxysuccinyl derivatives as selective inhibitors of cathepsin B
Articolo
Metabolic and conformational stabilization of a VEGF-mimetic betahairpin peptide by click-chemistry
Articolo
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the ?3?4 nicotinic acetylcholine receptor subtype
Articolo
Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides
Articolo
Multitarget opioid ligands in pain relief: New players in an old game
Recensione
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R)
Articolo
Neutral and charged phosphine/scorpionate copper(I) complexes: Effects of ligand assembly on their antiproliferative activity
Articolo
New comprehensive studies of a gold(III) Dithiocarbamate complex with. proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway
Articolo
New derivative of carnosine for nanoparticle assemblies
Articolo
New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity
Articolo
New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity.
Articolo
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains
Articolo
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment
Articolo
New naphthoquinone derivatives against glioma cells
Articolo
New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode
Articolo
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity
Articolo
New spirocyclic Delta(2)-isoxazoline derivatives related to selective agonists of alpha7 neuronal nicotinic acetylcholine receptors.
Articolo
Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors
Articolo
Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein
Articolo
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments
Articolo
Novel propanamides as fatty acid amide hydrolase inhibitors
Articolo
Novel pyrazole derivatives as neutral CB1 antagonists with significant activity towards food intake
Articolo
Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line
Articolo
Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer
Articolo
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation
Articolo
Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo
Articolo
PEG-Ara-C conjugates for controlled release.
Articolo
Peptidyl and azapeptidyl methylketones as substrate analog inhibitors of papain and cathepsin B
Articolo
Pharmacological characterization of a new series of carbamoylguanidines reveals potent agonism at the H2R and D3R
Articolo
Pirrolo[1, 2-f]phenantridines and Related Non-Rigid Analogues as Antiviral Agents
Articolo
Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for ?
4
?
2
nACh receptors
Articolo
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics
Articolo
RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.
Articolo
Rational design of allosteric modulators of the aromatase enzyme: An unprecedented therapeutic strategy to fight breast cancer
Articolo
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.
Articolo
Static and dynamic interactions between GALK enzyme and known inhibitors: Guidelines to design new drugs for galactosemic patients
Articolo
Straightforward synthesis of a novel ring-fused pyrazole-lactam and in vitro cytotoxic activity on cancer cell lines
Articolo
Strategies to target bioactive molecules to subcellular compartments. Focus on natural compounds
Articolo
Structural and biological characterization of new hybrid drugs joining an HDAC inhibitor to different NO-donors
Articolo
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX
Articolo
Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study
Articolo
Structural studies of the binding of an antagonistic cyclic peptide to the VEGFR1 domain 2
Articolo
Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents
Articolo
Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties
Articolo
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease
Articolo
Synthesis and Biophysical Evaluation of ARYLHYDRAZONO-1H-2-INDOLINONES as B-AMYLOID Aggregation Inhibitors
Articolo
Synthesis and HSA binding characterisation of the water soluble 7-succinylpaclitaxel
Articolo
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.
Articolo
Synthesis and activity of fibrillogenesis peptide inhibitors related to the 17-21 b-amyloid sequence
Articolo
Synthesis and activity of fibrillogenesis peptide inhibitors related to the 17-21 beta-amyloid sequence
Articolo
Synthesis and antioxidant activity of new homocarnosine beta-cyclodextrin conjugates.
Articolo
Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands
Articolo
Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.
Articolo
Synthesis and inhibiting activities of 1-peptidyl-2-haloacetyl hydrazines toward cathepsin B and calpains
Articolo
Synthesis of ibuprofen heterocyclic amides and investigation of their anlgesis and toxicological properties
Articolo
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease
Articolo
Synthesis of novel chiral Delta2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes
Articolo
Synthesis,
in vitro
and
in vivo
characterization of new benzoxazole and benzothiazole-based sigma receptor ligands
Articolo
Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[ b ]thiophene derivatives
Articolo
Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor
Articolo
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands
Articolo
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines.
Articolo
Synthesis, biological evaluation, and docking study of indole arylsulfonamides as aromatase inhibitors
Articolo
Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates
Articolo
TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives
Articolo
Taurultams incorporating arylsulfonamide: First in vitro inhibition studies of ?-, ?- and ?-class Carbonic Anhydrases from Vibrio cholerae and Burkholderia pseudomallei
Articolo
Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.
Articolo
Towards understanding the molecular recognition process in prokaryotic zinc-finger domain
Articolo
Tricyclic pyrazoles part 7. Discovery of potent and selective dihydrothienocyclopentapyrazole derived CB2 ligands
Articolo
Understanding the binding of daunorubicin and doxorubicin to NADPH-dependent cytosolic reductases by computational methods
Articolo
Unforeseen Alkylating Effect of Triethylorthoformate in the Synthesis of Pyrazolotriazolopyrimidine Derivatives
Articolo
No Results Found
«
‹
{pageNumber}
›
»
{startItem} - {endItem} di {itemsNumber}
5 per pagina
10 per pagina
30 per pagina
vedi tutti
