EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Journal

Identifier:

E060692

ISSN:

0223-5234

Overview

Outputs (123)

(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist

Academic Article

1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB(1) or CB(2) receptor ligands.

Academic Article

1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands.

Academic Article

2/4-Substituted-9-fluorenones and their O-glucosides as potential immunomodulators and anti-herpes simplex virus-2 agents. Part 5

Academic Article

A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-Tetrahydrobenzo[6,7]cyclohepta[1,2-c ]pyrazole-3-carboxamide and analogue derivatives

Academic Article

A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(20,40-dichlorophenyl)-N-piperidin-1-yl- 1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives

Academic Article

A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAFV600E in cancer cells

Academic Article

A novel 2,3-diphenyl-4H-pyrido[1,2-a]pyrimidin-4-one derivative inhibits endothelial cell dysfunction and smooth muscle cell proliferation/activation

Academic Article

An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors

Academic Article

Anti-inflammatory effects of flavonoids in neurodegenerative disorders

Academic Article

Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease

Academic Article

Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability

Academic Article

Benzothienoquinazolinones as new multi-target scaffolds: Dual inhibition of human Topoisomerase I and tubulin polymerization

Academic Article

Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: Modulation at the N-portion and distal phenyl ring

Academic Article

Bifunctional compounds targeting both D-2 and non-alpha 7 nACh receptors: Design, synthesis and pharmacological characterization

Academic Article

Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors

Academic Article

Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation

Academic Article

Chemical modifications in the seed region of miRNAs 221/222 increase the silencing performances in gastrointestinal stromal tumor cells.

Academic Article

Computational analysis of ligand recognition sites of homo- and heteropentameric 5-HT3 receptors

Academic Article

Conformational studies of chiral d-Lys-PNA and achiral PNA system in binding with DNA or RNA through a molecular dynamics approach

Academic Article

Conformationally constrained analogues of endogenous tripeptide inhibitors of zinc metalloproteinases.

Academic Article

DDX3X Inhibitors, an Effective Way to Overcome HIV-1 Resistance Targeting Host Proteins

Academic Article

Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R)

Academic Article

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

Academic Article

Design and synthesis of novel 3,4-disubstituted pyrazoles for nanomedicine applications against malignant gliomas

Academic Article

Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities for alpha(4)beta(2) neuronal nicotinic acetylcholine receptors

Academic Article

Design, structural and biological characterization of a VEGF inhibitor beta-hairpin-constrained peptide

Academic Article

Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-JK]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase

Academic Article

Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as a b-amyloid aggregation inhibitors.

Academic Article

Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.

Academic Article

Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors

Academic Article

Differential scanning calorimetry approach to investigate the transfer of the multitarget opioid analgesic LP1 to biomembrane model

Academic Article

Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for ? Opioid receptor for Safer and long-lasting analgesia

Academic Article

Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality

Academic Article

Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment

Academic Article

Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal

Academic Article

Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3

Academic Article

Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies

Academic Article

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl) benzenesulfonamide moiety

Academic Article

Exploring the anticancer potential of pyrazolo[1,2-a]benzo[1,2,3,4] tetrazin-3-one derivatives: The effect on apoptosis induction, cell cycle and proliferation

Academic Article

First dual AK/GSK-3beta inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

Academic Article

Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach

Academic Article

From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at ?4?2 nicotinic acetylcholine receptor

Academic Article

Homology modeling in tandem with 3D-QSAR analyses: a computational approach to depict the agonist binding site of the human CB2 receptor

Academic Article

Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus

Academic Article

Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease

Academic Article

Hydroxylated biphenyls as tyrosinase inhibitor: A spectrophotometric and electrochemical study

Academic Article

Identification of 2,4,5-trisubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one-based small molecules as selective BRD9 binders

Academic Article

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase

Academic Article

Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma

Academic Article

In silico drug repositioning on F508del-CFTR: A proof-of-concept study on the AIFA library

Academic Article

Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases

Academic Article

Iodo and diiodotyrosine epoxysuccinyl derivatives as selective inhibitors of cathepsin B

Academic Article

Metabolic and conformational stabilization of a VEGF-mimetic betahairpin peptide by click-chemistry

Academic Article

Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the ?3?4 nicotinic acetylcholine receptor subtype

Academic Article

Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides

Academic Article

Multitarget opioid ligands in pain relief: New players in an old game

Review

N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R)

Academic Article

Neutral and charged phosphine/scorpionate copper(I) complexes: Effects of ligand assembly on their antiproliferative activity

Academic Article

New comprehensive studies of a gold(III) Dithiocarbamate complex with. proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway

Academic Article

New derivative of carnosine for nanoparticle assemblies

Academic Article

New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity

Academic Article

New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity.

Academic Article

New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains

Academic Article

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

Academic Article

New naphthoquinone derivatives against glioma cells

Academic Article

New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode

Academic Article

New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity

Academic Article

New spirocyclic Delta(2)-isoxazoline derivatives related to selective agonists of alpha7 neuronal nicotinic acetylcholine receptors.

Academic Article

Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors

Academic Article

Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein

Academic Article

Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments

Academic Article

Novel propanamides as fatty acid amide hydrolase inhibitors

Academic Article

Novel pyrazole derivatives as neutral CB1 antagonists with significant activity towards food intake

Academic Article

Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line

Academic Article

Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer

Academic Article

Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation

Academic Article

Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo

Academic Article

PEG-Ara-C conjugates for controlled release.

Academic Article

Peptidyl and azapeptidyl methylketones as substrate analog inhibitors of papain and cathepsin B

Academic Article

Pharmacological characterization of a new series of carbamoylguanidines reveals potent agonism at the H2R and D3R

Academic Article

Pirrolo[1, 2-f]phenantridines and Related Non-Rigid Analogues as Antiviral Agents

Academic Article

Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for ?4?2nACh receptors

Academic Article

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics

Academic Article

RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.

Academic Article

Rational design of allosteric modulators of the aromatase enzyme: An unprecedented therapeutic strategy to fight breast cancer

Academic Article

Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.

Academic Article

Static and dynamic interactions between GALK enzyme and known inhibitors: Guidelines to design new drugs for galactosemic patients

Academic Article

Straightforward synthesis of a novel ring-fused pyrazole-lactam and in vitro cytotoxic activity on cancer cell lines

Academic Article

Strategies to target bioactive molecules to subcellular compartments. Focus on natural compounds

Academic Article

Structural and biological characterization of new hybrid drugs joining an HDAC inhibitor to different NO-donors

Academic Article

Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX

Academic Article

Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study

Academic Article

Structural studies of the binding of an antagonistic cyclic peptide to the VEGFR1 domain 2

Academic Article

Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents

Academic Article

Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties

Academic Article

Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease

Academic Article

Synthesis and Biophysical Evaluation of ARYLHYDRAZONO-1H-2-INDOLINONES as B-AMYLOID Aggregation Inhibitors

Academic Article

Synthesis and HSA binding characterisation of the water soluble 7-succinylpaclitaxel

Academic Article

Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.

Academic Article

Synthesis and activity of fibrillogenesis peptide inhibitors related to the 17-21 b-amyloid sequence

Academic Article

Synthesis and activity of fibrillogenesis peptide inhibitors related to the 17-21 beta-amyloid sequence

Academic Article

Synthesis and antioxidant activity of new homocarnosine beta-cyclodextrin conjugates.

Academic Article

Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands

Academic Article

Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.

Academic Article

Synthesis and inhibiting activities of 1-peptidyl-2-haloacetyl hydrazines toward cathepsin B and calpains

Academic Article

Synthesis of ibuprofen heterocyclic amides and investigation of their anlgesis and toxicological properties

Academic Article

Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease

Academic Article

Synthesis of novel chiral Delta2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes

Academic Article

Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands

Academic Article

Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[ b ]thiophene derivatives

Academic Article

Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor

Academic Article

Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands

Academic Article

Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines.

Academic Article

Synthesis, biological evaluation, and docking study of indole arylsulfonamides as aromatase inhibitors

Academic Article

Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates

Academic Article

TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives

Academic Article

Taurultams incorporating arylsulfonamide: First in vitro inhibition studies of ?-, ?- and ?-class Carbonic Anhydrases from Vibrio cholerae and Burkholderia pseudomallei

Academic Article

Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.

Academic Article

Towards understanding the molecular recognition process in prokaryotic zinc-finger domain

Academic Article

Tricyclic pyrazoles part 7. Discovery of potent and selective dihydrothienocyclopentapyrazole derived CB2 ligands

Academic Article

Understanding the binding of daunorubicin and doxorubicin to NADPH-dependent cytosolic reductases by computational methods

Academic Article

Unforeseen Alkylating Effect of Triethylorthoformate in the Synthesis of Pyrazolotriazolopyrimidine Derivatives

Academic Article

No Results Found

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Overview

Outputs (123)