Gene Expression Profiling in Melanoma

One of the big challenges in cancer research is to identify genomic alterations responsible for genesis and progression of disease. Melanoma is one of the most difficult tumours to treat for its aggressiveness, strong therapeutic resistance and proclivity for late metastasis. Here we describe the new gene high-throughput technologies, microarray and next-generation sequencing (NGS), and their impact in melanoma research. We illustrate their use from the discovery of melanoma biomarkers and therapeutic targets to clinical applications including patients' classification and stratification.