Differentiation plasticity of germline cell-derived pluripotent stem cells and their potential application in regenerative medicine

Pluripotent stem cells hold the key to replacing cells lost in many degenerative diseases. Stem cells can be differentiated into specialized cell types and can be a useful source of healthy cells in genetic disease, especially those which can be corrected by only a small amount of functional protein. In the last years impressive efforts have been made in understanding the potential application of pluripotent stem cells in the field of regenerative medicine. In these review, we will discuss the differentiation plasticity of mouse Germline Cell-derived Pluripotent Stem Cells (GPSCs) into different cell types with the aim to translating these potentialities to human organ regeneration.