Amyloid-beta Oligomers-induced Mitochondrial DNA Repair Impairment Contributes to Altered Human Neural Stem Cell Differentiation

Academic Article
Publication Date:
2019
abstract:
Background: Amyloid-beta(42) oligomers (A beta O-42), the proximate effectors of neurotoxicity observed in Alzheimer's disease (AD), can induce mitochondrial oxidative stress and impair mitochondrial function besides causing mitochondrial DNA (mtDNA) damage. A beta O-42 also regulate the proliferative and differentiative properties of stem cells.
Iris type:
01.01 Articolo in rivista
Keywords:
Amyloid-?; mitochondria; DNA damage; DNA repair; human neural stem cell; differentiation.; Amyloid-beta; mitochondria; DNA damage; DNA repair; human neural stem cell; differentiation
List of contributors:
Authors of the University:
Handle:
https://iris.cnr.it/handle/20.500.14243/366854
Published in:
CURRENT ALZHEIMER RESEARCH (PRINT)
Journal