Amyloid-beta Oligomers-induced Mitochondrial DNA Repair Impairment Contributes to Altered Human Neural Stem Cell Differentiation
Articolo
Data di Pubblicazione:
2019
Abstract:
Background: Amyloid-beta(42) oligomers (A beta O-42), the proximate effectors of neurotoxicity observed in Alzheimer's disease (AD), can induce mitochondrial oxidative stress and impair mitochondrial function besides causing mitochondrial DNA (mtDNA) damage. A beta O-42 also regulate the proliferative and differentiative properties of stem cells.
Tipologia CRIS:
01.01 Articolo in rivista
Keywords:
Amyloid-?; mitochondria; DNA damage; DNA repair; human neural stem cell; differentiation.; Amyloid-beta; mitochondria; DNA damage; DNA repair; human neural stem cell; differentiation
Elenco autori:
Mollinari, Cristiana
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