MIR-182 is a Tbx5 effector during heart development in zebrafish

MicroRNAs, small molecules of 22-25 nt, inhibit translation of target mRNAs and with transcription factors comprise two major layers of gene regulatory networks with strictly intercon- nected activities. Tbx5, a dosage sensitive gene, is a pivotal player involved in heart/limbs development and its mutations are responsi- ble of the Holt-Oram syndrome (HOS) in human, characterized by upper limb malformations and congenital heart defects (CHD)s both in morphology and electrophysiology.