Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
Academic Article
Publication Date:
2019
abstract:
Intrinsically disordered proteins (IDPs) do not have a well-defined structure, but they have key biological tasks in cancer development. By using the disordered cancer-related protein NUPR1 as a proof-of-concept, we have developed a new multidisciplinary approach to tackle drug-design against IDPs, using it to repurpose drugs for treating pancreatic adenocarcinoma (PDAC).
Iris type:
01.01 Articolo in rivista
Keywords:
Drug design; intrinsically disordered protein; molecular dynamics; NUPR1; protein-protein interactions; spectroscopy
List of contributors:
Rizzuti, Bruno
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