Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
Articolo
Data di Pubblicazione:
2019
Abstract:
Intrinsically disordered proteins (IDPs) do not have a well-defined structure, but they have key biological tasks in cancer development. By using the disordered cancer-related protein NUPR1 as a proof-of-concept, we have developed a new multidisciplinary approach to tackle drug-design against IDPs, using it to repurpose drugs for treating pancreatic adenocarcinoma (PDAC).
Tipologia CRIS:
01.01 Articolo in rivista
Keywords:
Drug design; intrinsically disordered protein; molecular dynamics; NUPR1; protein-protein interactions; spectroscopy
Elenco autori:
Rizzuti, Bruno
Link alla scheda completa:
Pubblicato in: