Hydrogel-drug release molecualr interactions and mobility a proton HRMAS NMR diffusion study

In relation to drug release properties, hydrogels are widely investigated as new biocompatible polymers for in situ controlled drug delivery. The interpretation of transport phenomena of small drug molecules in a polymeric network is essential for a good device design. A comprehensive theory for these systems is controversial and still lacks. In this framework, the new NMR technique HRMAS-DOSY is used to study the diffusive motion of several target drug-like molecules loaded in hydrogels. The experimental results are innovative and used to propose a new model to explain the drug-matrix interactions