Total synthesis of a Pepstatin analogue incorporating two trifluoromethyl hydroxymethylene isosteres

Academic Article
Publication Date:
2000
abstract:
The total synthesis of a trifluoromethyl (Tfm) analogue of the aspartate protease inhibitor Pepstatin has been accomplished via incorporation of two ?-Tfm-amino ?-hydroxy peptide isosteres instead of the natural statine units. The title compound as well as several Tfm-substituted precursors did not show anti-HIV activity. (C) 2000 Elsevier Science Ltd.
Iris type:
01.01 Articolo in rivista
Keywords:
Enzyme inhibitors; Pepstatin; Peptide mimetics; Trifluoromethyl group
List of contributors:
Handle:
https://iris.cnr.it/handle/20.500.14243/279267
Published in:
TETRAHEDRON LETTERS
Journal