Total synthesis of a Pepstatin analogue incorporating two trifluoromethyl hydroxymethylene isosteres
Articolo
Data di Pubblicazione:
2000
Abstract:
The total synthesis of a trifluoromethyl (Tfm) analogue of the aspartate protease inhibitor Pepstatin has been accomplished via incorporation of two ?-Tfm-amino ?-hydroxy peptide isosteres instead of the natural statine units. The title compound as well as several Tfm-substituted precursors did not show anti-HIV activity. (C) 2000 Elsevier Science Ltd.
Tipologia CRIS:
01.01 Articolo in rivista
Keywords:
Enzyme inhibitors; Pepstatin; Peptide mimetics; Trifluoromethyl group
Elenco autori:
Panzeri, Walter
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