In vitro experiments and in vivo implants to evaluate a new silicone-based polyurethane material for replacement of small vessels.

The idea underscoring our proposed development is to take advantage of the good properties of both polyurethanes (PU) and silicones (PDMS). The attributes which make polyurethanes attractive as materials for biomedical applications are their excellent physical-chemical properties, and their relatively good biocompatibility. Against their use is the phenomenon of biodegradation that occurs after long-term implantation. Silicones, on the other end, are known to have long-term biostability and good haemocompatibility subsequent to their use in several biomedical settings.