A point of care (POC) device for C-reactive protein, procalcitonin and neopterin detection

In this work a fluorescence-based optical device is described capable to measure the concentration of PCT, CRP and neopterin in serum. The heart of the system is a two-piece polymethylmetacrylate (PMMA) chip, with microchannels through which the analysed sample flows. The fluorescence, which comes from the sensing layer where the specific biologic interaction takes place, is guided by PMMA waveguides which run along the microchannels to an optical fibre connected to an optical spectrum analyser.