Photodynamic activity of thiophene-derived lysosome-specific dyes

The photodynamic activity occurring through the lysosome photo-damage is effective in terms of triggered synergic effectswhich can avoid chemo-resistance pathways. The potential photodynamic activity of twofluorescent lysosome-specific probes was studied providing their interaction with human serum albumin, demonstrating their in vitro generation of singlet oxygen and investigating the resulted photo-toxic effect in human cancer cells.