Enzyme catalyzed reactions

The name enzyme (from Greek ?????? = to ferment) was first used by W. Kühne in 1867 to indicate ferments or "active agents of fermentations". In 1893, F.W. Ostwald demonstrated that enzymes are biological catalysts. Im 1894 E. Fischer proposed his famous "Lock-and key" concept of enzymes specificity, as he wrote: "I would say that the enzyme and the glucoside must fit each other like a lock and key, in order to effect a chemical reaction on each other". The lock and key concept offered a simple explanation for the biological asymmetric synthesis and it has played an important role in the development of our understanding of enzyme mechanisms. However, it has led to the popular misconception "one enzyme-one substrate".