Control of Motor Function by Adenosine A2A Receptors in Parkinson's and Huntington's Disease

Adenosine A2A receptors are predominantly expressed in the basal ganglia (BG) circuitry, which is responsible for the integration of sensorimotor information that controls the planning and initiation of voluntary movement. Moreover, the caudate-putamen (CPu) or striatum and nucleus accumbens contain higher concentrations of these receptors. Of great importance for adenosine A2A receptor control of motor functions is their colocalization with the dopamine (DA) D2 receptors.