Antifeedant activity of neo-clerodane diterpenoids from Teucrium fruticans and derivatives of fruticolone

The antifeedant activity of three neo-clerodane diterpenoids, fruticolone, isofruticolone and fruticolide from Teucrium fruticans was assessed using larvae of Spodoptera littoralis. Isofruticolone was one of the most potent of the Teucrium derived neoclerodanes. Chemical modification of functional groups on fruticolone showed that its activity could be enhanced.