Lack of evidence that CYTH2/ARNO functions as an intracellular EGFR activator

The EGFR instructs complex cellular programs by generating robust signals of defined strength and duration. To preserve signal identity and guard cells against the oncogenic risk generated by unabated signaling, it is imperative that EGFR be tightly regulated. In this framework, the ligand-dependent transition of EGFR from an inactive state to a catalytically competent one is regarded as a key control step. In absence of ligand, the EGFR adopts a default auto-inhibited conformation that is relieved by EGF binding and attendant stabilization of EGFR dimers...http://www.cell.com/cell/abstract/S0092-8674(16)30557-8