Hydroxylation, Epoxidation and Related Reactions

aluablea-hydroxy acids are conveniently synthesized with relevant selectivityenhancement using a sol-gel hydrophobized nanostructured silica matrix doped withthe organocatalyst TEMPO [Silia*Cat*TMTEMPO] and bleach as primary oxidant,coupled with rapid RuO4-mediated olefin dihydroxylation (Figure 6.1).[1,2]The porousstructure of the fully methyl-modified organically modified silicate (ORMOSIL)xerogel dictates the accessibility of the diol molecules to the entrapped catalystlimiting oxidative cleavage and at the same time preventing catalyst deactivation.