Biocompatibility of biphasic alpha,beta-tricalcium phosphate ceramics in vitro

The biocompatibility of biphasic alpha,beta-tricalcium phosphate ceramics, obtained by annealing a compact preform based on beta-tricalcium phosphate powder, was studied in vitro. It was found that within 10-30 days the adhesion of primary dental pulp stem cells located on the surface of biphasic alpha,beta-tricalcium phosphate ceramics is suppressed. Decrease of the cell number on the surface of biphasic alpha,beta-tricalcium phosphate ceramics, most likely, can be associated with both the pH level (acidic) as a result of hydrolysis of the more soluble phase of alpha-tricalcium phosphate and with the nature of surface that changes as a result of the formation and growth of hydroxyapatite crystals.