Hydroformylation of Terminal Alkenes Supported on Solid Phase. A New Synthetic Tool for Combinatorial Chemistry

The hydroformylation and the tandem hydroformylation-reductive amination reactions have been applied first time on solid phase. The work demonstrates that the cited reactions can be carried out successfully on terminal alkenes supported on PS-DVB resins with classsical trityl or Wang linkers. The application of this tecnology is the preparation of libraries of small organic molecules and natural like compounds.