Modulation of methotrexate efficacy by green tea polyphenols in rat adjuvant arthritis

Background: Green tea catechins are widely employed as dietary supplements to restore the oxidative state in adjuvant-induced arthritic rats, a model for human rheumatoid arthritis. Methotrexate is the first line anti rheumatic drug. The present study aimed to investigate if a decaffeinated extract (GreenSelect (R), GS) of tea polyphenols can ameliorate methotrexate treatment in rat adjuvant arthritis.