A network-based algorithm for identifying drug repurposing opportunities for complex diseases

SAveRUNNER is a recently developed network-based tool to efficiently identify novel medical indications for currently approved drugs (known as drug repurposing strategy). Up to now, SAveRUNNER has been gainfully applied to unveil repurposable solutions for several diseases, including viral infection (e.g., SARS, COVID-19, HIV, Malaria, Ebola), breast cancer, progressive disorders of central nervous system (e.g., Amyotrophic Lateral Sclerosis, Multiple Sclerosis), and other neurodegenerative diseases (e.g., Alzheimer's Disease). Here, SAveRUNNER algorithm and its main applications are described. © 2023 Convegno Nazionale di Bioingegneria. All rights reserved.