Synthesis of 3-Butadienyl-1-tosylpyrroles

A pathway for the formation of 3-butadienyl-1-tosylpyrroles from 3-acyl derivatives via secondary and tertiary 3-hydroxyalkyl-1-tosylpyrroles has been developed. The dehydration of the alcohols intermediates is the crucial step: conditions for high chemo- and diastereocontrol are described. © 2014 HeteroCorporation.