Surface adsorption of fibronectin-derived peptide fragments: the influence of electrostatics and hydrophobicity for endothelial cells adhesion

The adsorption on hydrophobic and hydrophilic silica-based surfaces of the integrin-binding PHSRN peptide and the single-residualmutated analogues, PHSEN and PHSFN, is investigated by comparative QCM-D, XPS, SFG measurements and molecular dynamics calculations. Endothelial cell cultures on the peptidefunctionalized materials highlight their tunable pro- or anti-angiogenic potentia