Effective enzymatic resolution of rac-1-(3-trifluoromethylphenyl)propan-2-ol, precursor of fenfluramine.

Academic Article
Publication Date:
2002
abstract:
Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac-1-(3-trifluoromethylphenyl)propan-2-ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine.
Iris type:
01.01 Articolo in rivista
Keywords:
drug; lipase; biocatalysis; enantiomer; chirality
List of contributors:
Authors of the University:
Handle:
https://iris.cnr.it/handle/20.500.14243/161136
Published in:
CHIRALITY (N.Y., N.Y. PRINT)
Journal