Natural Fluorescence Imaging of Leukemic Cells for Studying Uptake and Retention of Anthracyclines

Cells exposed to light of appropriate wavelength show fluorescence emission in the UV-visible spectral range. This phenomenon, called natural fluorescence (NF), is related to cell compounds, i.e. proteins (1), nicotinic coenzymes (2), flavins (3), etc., engaged in structural and metabolic processes. Thus a correlation does exist between NF emission and morpho-functional state of cells.