OUTER-SPHERE LIGAND-EXCHANGE CHROMATOGRAPHY OF NUCLEOTIDES AND RELATED-COMPOUNDS ON A MODIFIED POLYSACCHARIDE GEL

In this paper the preparation of a cross-linked dextran gel (Sephadex G-75) with amino-cobalt(IiI) complex groups is described. This phase is obtained by reaction of an aminobutyl-Sephadex derivative with [Co(tetren)Cl]2+. The separation of some mono- and dinucleotides on this support has been achieved.