Antimold microbial and plant metabolites with potential use in intelligent food packaging.

Molds food infestation is a heavy dangerous problem for human health and also could generate heavy economic losses. The intelligent packaging using eco-friendly biodegradable biofilm incorporating bioactive natural safe compounds represents a new frontier. This manuscript reports the inhibitory activity of twelve bacterial, fungal, and plant metabolites against Penicilliumroqueforti and Aspergillus niger.Among them ?-costic acid and ungeremine (3 and 12) are the most promising as potential biofungicide against both fungal strains.They inhibited fungal growth by more than 60% respect to the control at 72h and this activity persisted also at 96h. Ungeremine showed MIC90 lower than 0.003 mg/mL after 48h of incubation and of 0.025 mg/mL at 72h against P. roqueforti. The MIC90 value forA. niger was 0.2 mg/mL at 48h for both compounds. The ?-costic acid showed generally MIC values at 48 and 72h higher than ungeremine.