Amyloid beta Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies

Researchers present an in-depth review on the contribution of biophysical and biochemical studies and computer simulations to characterize the molecular structures of A?1-40/1-42 monomers, oligomers, protofibrils, and amyloid fibrils in aqueous solution. They focus their current knowledge of the A?1-40/1-42 nucleus and the structures and dynamics of A?1-40/1-42 oligomers in proximity of or at the membrane. They also the available information regarding the interactions of A? monomers and oligomers with ion metals, cellular partners, and potential inhibitors.