Release of bioactive peptides and quercetin during mastication of fortified chewing-gum

Chewing gums containing 10% of remineralizing caseino-phosphopeptides (CPP) and 1% of "antibacterial" quercetin (Q) have been produced to be used in prevention and/or in the early onset of caries pathology. To this aim, in this study the release of both components was monitored in human and artificial saliva by means of chromatographic and mass spectrometry analysis. The results achieved showed that, in both cases, the highest amount of components was released after the first five minute of chewing and, unlike the artificial salivary extract that human exhibited a very poor profile than the included raw material.