Advanced targeting approaches to drive nanoparticles inside the body

It was demonstrated that the extent of specific internalization of targeted NPs could be improved by regulating the length of the PEG chains in PCL-b-PEG copolymers to attain stealth properties and in PCL-b-PEG-Fol to ameliorate Fol exposition on NP surface. This study was devoted to demonstrate this hypothesis by producing NPs from PCL-b-PEG with short PEG chains (1000 kDa, to confer stealth properties) and a PCL-b-PEG-Fol with long PEG chain (1500 Da, to confer improved targeting ability).