ICTV Virus Taxonomy Profile: Hypoviridae 2023

Hypoviridae is a family of capsidless viruses with positive- sense RNA genomes of 7.3-18.3 kb that possess either a single laropen reading frame (ORF) or two ORFs. The ORFs appear to be translated from genomic RNA by non- canonical mechanisms, i.e.internal ribosome entry site- and stop/restart translation. This family includes the genera Alphahypovirus, Betahypovirus, Gammahypovirus, Deltahypovirus, Epsilonhypovirus, Zetahypovirus, Thetahypovirus and Etahypovirus. Hypovirids have been detected in ascomycetous and basidiomycetous filamentous fungi and are considered to replicate in host, Golgi apparatus- derived, lipid vesicles that contain virus dsRNA as the replicative form. Some hypovirids induce hypovirulence to host fungi, while others do not. This is a summary of the ICTV report on the family Hypoviridae, which is available at www.ictv.global/report/hypoviridae