Copper Oxide Nanoparticles over Hierarchical Silica Monoliths for Continuous-Flow Selective Alcoholysis of Styrene Oxide

A simple and reproducible approach for the synthesis of Cu-based heterogeneous catalysts, named flow chemisorption hydrolysis (flow-CH), is reported. The approach, derived from the CH method, allows size-controlled CuO nanoparticles (mean diameter 2.9 nm) to be obtained, that are highly and homogeneously dispersed into hierarchically meso-/macroporous silica monoliths. The Cu-based monolithic catalysts (CuO@SiO2-MN, 8.4 wt.% Cu) were studied in the styrene oxide ring opening reaction at 60 °C in the presence of isopropanol, under continuous flow-through conditions. A remarkable activity with a steady-state conversion of 97% for 13 h and 100% selectivity towards the corresponding ?-alkoxyalcohol was observed. The performances of CuO@SiO2-MN were higher than those obtained in batch conditions with the previously reported CuO/SiO2 catalysts and with the ground CuO@SiO2-MN monolith in terms of productivity and selectivity. Moreover, a negligible Cu leaching (<0.6 wt.%) in reaction medium was observed. After 13 h CuO@SiO2-MN catalysts could be regenerated by a mild calcination (220 °C) permitting reuse.