Structural Isomers of Cyclodextrin-Bearing IOX1 Compound as Inhibitors of Abeta Aggregation

Alzheimer?s disease represents a daunting challenge for healthcare because it affects millions of people worldwide. The abnormal assembly of amyloid-beta peptides into amyloid aggregates is a pathological hallmark of Alzheimer's disease. Properly functionalized cyclodextrins modulate amyloidogenesis. Here, we report the synthesis and characterization of a 6-monofunctionalized cyclodextrin-bearing a quinoline derivative (IOX1). Moreover, we tested the ability of the new compound and its 3-monofunctionalized isomer to inhibit self-induced A? aggregation in order to understand if the two isomers differently modulate aggregation process. The results further establish the potential of cyclodextrin conjugates as modulators of A? aggregation.