High resolution, hand held camera for sentinel node detection

Background: The imaging probe (IP) is a high-resolution (HR), 1-in2 field-of-view hand-held gamma camera. We used it to detect breast cancer sentinel node (SN). Patients and Methods: We divided 120 T1 breast cancer patients, who underwent Anger camera lymphoscintigraphy (ACL), in two subgroups of 60 patients who were age, body mass index, and cancer size matched: subgroup A (SA) and B (SB). SN was detected with a common gamma probe (GP) in SA, with IP plus GP in SB. Results: Surgeons removed radioactive nodes without exceeding four nodes. Eighty-two (82) SNs were taken off in SA and 105 in SB (p < 0.01). Of SA, 22 of 60 patients and 36 of 60 patients of SB showed more than 1 node, and 3 of them showed 3 nodes and 1 showed 4 nodes. Thirteen (13) patients resulted N+ (21.6%) in SA. Ten (10) patients of SA showed an invasion on the hottest nodes and 3 on the second nodes. In the SB, 18 patients (25%) showed invasion. Sixteen (16) invasions were on hot, 4 on second, and 1 on the third node. Withdrawal time of SN was 11.25 ± 4.7 minutes for SA and 7.4 ± 2.8 minutes for SB (p < 0.025). Conclusions: SN biopsy with IP is fast and discovers more SNs and more invasions than ACL.