A New Sequential Intramolecular Cyclization Based on the Boekelheide Rearrangement

Pyrrolidines and piperidines were synthesized from (amino-alkyl)pyridine N-oxides with a general and quite efficient method developed by using di-tert-butylsilyl bis(trifluoro-methanesulfonate) as a new promoter for a Boekelheide-type reaction. The use of a new Boekelheide promoter, which is compatible with amino groups, opens new perspectives in view of its application in intramolecular cyclizations.