Fluorescence Monitoring of Microchip Capillary Electrophoresis Separation with Monolithically Integrated Optical Waveguides

Femtosecond-laser-written waveguides were integrated with fluidic microchannels in a commercial lab-on-a-chip. High-spatial-resolution. monitoring of fluorescently labeled DNA molecules during capillary electrophoresis separation is demonstrated, as an intermediate step toward point-of-care diagnostic bioassays for DNA analysis. (C) 2009 Optical Society of America