1,2,3-triazole bridge as conformational constrain in ?-hairpin peptides: Analysis of hydrogen-bonded positions

Conformational constrained ?-hairpin peptides are useful tool to modulate protein-protein interactions. A triazole bridge in hydrogen-bonded positions between two antiparallel strands induces a conformational stabilization of the ?-hairpin peptide. The entity of the stability of the ?-hairpin peptide depends on the length of the bridge.