An in vitro model for the study of anti-HIV oligonucleotides

An experimental model is utilized that enable evaluation of the anti-HIV activity of selective compounds, without the need for growing the infected virus. Besides, the system reproduce condition more akin to those of chronically infected cells. i.e. lack of sensitivity to conventional chemotherapeutic agents and limited possibility for adopting an approach of "intracellular immunization". Due to their nuclease resistance, L-2'-deoxynucleotides may form the basis for developing a new class of compounds having a phosphorothioate core structure and protected termini.