Preparation and reactivity of [2-(3-methyl-4-nitro-isoxazol-5-yl)-vinyl]-amines

Herein, we report our investigation into the reactivity of 5-enamino-4-nitroisoxazoles. This study revealed that the title compounds, in spite of conjugation to the 4-nitroisoxazole, displayed similar reactivity to enamines, reacting with electrophiles to form new C-C, C-N, and C-Cl bonds. (C) 2015 Elsevier Ltd. All rights reserved.