Data di Pubblicazione:
2015
Abstract:
Microglialcellsparticipateinbraindevelopmentandinfluenceneuronallossandsynapticmaturation.Fractalkineisanimportantneuronalchemokinewhoseexpressionincreasesduringdevelopmentandthatcaninfluencemicrogliafunctionviathefractalkinereceptor,CX3CR1.MicelackingCx3cr1showavarietyofneuronaldefectsthoughttobetheresultofdeficientmicrogliafunction.ActivationofCX3CR1isimportantforthepropermigrationofmicrogliatositesofinjuryandintothebrainduringdevelopment.However,littleisknownabouthowfractalkinemodulatesmicroglialpropertiesduringdevelopment.Hereweexaminedmicroglialmorphology,responsetoATP,andK+currentpropertiesinacutebrainslicesfromCx3cr1knockoutmiceacrosspostnatalhippocampaldevelopment.Wefoundthatfractalkinesignalingisnecessaryforthedevelopmentofseveralmorphologicalandphysiologicalfeaturesofmicroglia.Specifically,wefoundthattheoccurrenceofanoutwardrectifyingK+current,typicalofactivatedmicroglia,thatpeakedduringthesecondandthirdpostnatalweek,wasreducedinCx3cr1knockoutmice.FractalkinesignalingalsoinfluencedmicroglialmorphologyandabilitytoextendprocessesinresponsetoATPfollowingitsfocalapplicationtotheslice.Ourresultsrevealthedevelopmentalprofileofseveralmorphologicalandphysiologicalpropertiesofmicrogliaanddemonstratethattheseprocessesaremodulatedbyfractalkinesignaling.
Tipologia CRIS:
01.01 Articolo in rivista
Keywords:
potassium currents; rearrangement; development; fractalkine; CX3CR1; microglia
Elenco autori:
Cortese, Barbara; Pagani, Francesca
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