OPIOID-PEPTIDES IN MICELLAR SYSTEMS - CONFORMATIONAL-ANALYSIS BY CD AND BY ONE-DIMENSIONAL AND 2-DIMENSIONAL H-1-NMR SPECTROSCOPY

beta-Endorphin has been studied in SDS micelles by one- and two-dimensional nmr spectroscopy (1D and 2D nmr), and to explore the influence of peptide length and composition on the polypeptide structure, the investigation was extended to a number of fragments. The nmr results are compared with those obtained from CD experiments and discussed in terms of a secondary structure that involves the central region of beta-endorphin.