Generation and functions of second messengers microdomains

A compelling example of the mechanisms by which the cells can organize and decipher complex and different functional activities is the convergence of a multitude of stimuli into signalling cascades, involving only few intracellular second messengers. The possibility of restricting these signalling events in distinct microdomains allows a fine and selective tuning of very different tasks. In this review, we will discuss the mechanisms that control the formation and the spatial distribution of Ca2+ and cAMP microdomains, providing some examples of their functional consequences.