Modulation of neural differentiation by the essential gene PC3/Tis21 and its effects on memory formation

Neurogenesis in the dentate gyrus of the adult hippocampus has been implicated in neural plasticity and memory, but the molecular mechanisms controlling the proliferation and differentiation of newborn neurons and their integration into the synaptic circuitry are still largely unknown. To investigate this issue, we have analyzed the processes controlling the differentiation of new adult hippocampal neurons and the effects of its alteration on memory.