ACTIVATION OF PROTEIN PHOSPHATASE 2A IS RESPONSIBLE FOR INCREASED CONTENT AND INACTIVATION OF RESPIRATORY CHAIN COMPLEX I INDUCED BY ALL-TRANS RETINOIC ACID IN HUMAN KERATINOCYTES

This study presents the effect of all-trans retinoic acid (ATRA) on cell growth and respiratory chain complex I in human keratinocyte cultures. Keratinocyte treatment results in increased level of GRIM- 19 and other subunits of complex I, in particular of their carbonylated forms, associated with inhibition of its enzymatic activity. The results show that in keratinocytes ATRA-promoted phosphatase activity controls the proteostasis and activity of conplex I.