Genetic loci influencing kidney function and chronic kidney disease

Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function. Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease. Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease