Determination of chlorthalidone and its impurities in bulk and in dosage forms by high-performance thin-layer chromatographic densitometry

This paper describes a simple and rapid method for determining the chlorthalidone and its impurities 4'-chloro-3'-sulphamoyl-2-benzophenonecarboxylic acid and [2-chloro-5-(1-methoxy-3-oxo-1-isoindolinyl)benzenesulphonamide] by scanning quenched zones on high-performance silica gel F254.