A new approach to non racemic saturated and unsaturated 5-aminoalkyl methyl ketones

Non racemic t-Boc protected aminoalkyl ketones have been obtained starting from ?-stannylated (E)-allylamines through a high yielding two step procedure consisting of a Stille coupling and a subsequent Wacker oxidation. These compounds are useful intermediates for obtaining 2,6-disubstituted piperidines.